Multifunctional Magnetic Nanoparticles for Dynamic Imaging and Therapy

Multifunctional magnetic nanoparticles (MNPs) exhibit unique properties, such as remote motion controllability, degradability, and diagnostic imaging, which are typically not shown in nonmagnetic nanomaterials. MNPs remotely controllable via fields offer advantages of high tissue penetrability biocompatibility. In this review, recent advances multifunctional exhibiting characteristic for therapeutic applications summarized, utilize the “dynamic” motion, iron ion degradation, or imaging-guided targeting under diverse field modes. The field-controlled MNP enables spatiotemporal reversible situ cell regulation mechanosensitive molecule modulation thermal energy generation. Furthermore, iron-based can produce degraded ions reactive oxygen species to enable targeted ferroptosis therapy with medical approaches. state-of-the-art using that provide feedback at each stage is highlighted. Potential hurdles translating dynamic imaging toward clinical practices also discussed. capability during magneto-cell noninvasive, safe, localized, on-demand regenerative therapy, immunotherapy, cancer treatment.